Mechanistically, thirst starts with the excitation of osmoregulatory cells in a brain structure called the lamina terminalis, which is located in the anterior wall of the third ventricle. The lamina ...

Medically reviewed by Danielle Weiss, MDMedically reviewed by Danielle Weiss, MD Diabetes insipidus (DI) is a rare disorder in which the body cannot properly regulate fluids. It is not related to the ...

Aquaporin-2 (AQP2) is a critical water channel in the renal collecting ducts that governs water reabsorption and urine concentration. Dysregulation of AQP2, through genetic mutations or acquired ...

X-linked nephrogenic diabetes insipidus (XNDI) is a severe congenital kidney disease caused by mutations in the V2R gene. Currently, there is no effective drug to specifically treat XNDI, mainly ...

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