In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells to ...

Pharmacogenomic trial of CPT-11-docetaxel in untreated patients (P) with advanced non small cell lung cancer (NSCLC). A phase II study of the Spanish Lung Cancer Group (SLCG). Correlation with the ...

(Philadelphia, PA) – Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors. As tumors grow ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However, previous ...

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: ...

mRNA nanoparticles effectively and safely restored the function of the p53 tumor-suppressor gene in hepatocellular carcinoma models. When used in combination with immune checkpoint blockade, the mRNA ...

A long noncoding RNA (lncRNA), the RNA component of mitochondrial RNA-processing endoribonuclease (RMRP), was shown to promote the growth and proliferation of colorectal cancer (CRC) cells by ...

Proteins that are frequently altered in tumors play a prominent role in cancer research. The protein RFX7, a largely unknown transcription factor, has recently been linked to lymph node cancer.

Follicular lymphoma is a slow-growing yet incurable form of non-Hodgkin lymphoma. New research is shedding light on the molecular causes of this type of cancer. Scientists have identified a gene that ...

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now scientists have discovered a new role for p53 in its fight against tumors: preventing ...