Researchers showed that in C. elegans, the protein MBD-2 regulates genes through repressive histone marks rather than DNA ...
This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...
Human disease including cancer arises from disfunction of essential processes within a cell. One essential cellular process is the copying of the genomic DNA—the road map of cells—followed by ...
DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...
Histone Kla regulates tumor angiogenesis by affecting the levels of downstream HIF1-ɑ and Vegf. In non-histone proteins, YY1-Kla influences FGF2, and Sema3A-Kla affects HIF1-ɑ, both contributing to ...
Before a newly synthesized protein can undergo folding, it must be processed and transported to the correct location within the cell after emerging from the ribosome. N-terminal acetylation ...
A collaborative effort has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of ...
DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...
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